Doppel

Doppel (Dpl), named for downstream prion protein-like, is a homolog of the prion protein (PrP). It is a cell surface glycoprotein.

Structure of Dpl
Dpl has the same fold as the C-terminal domain PrP, with three alpha helices and two short beta strands. However Dpl differs from PrP in two important respects: the second helix of Dpl has a pronounced kink in it, and Dpl also contains two disulphide bonds.

The structure mutant PrP with the additional disulphide bond was also determined

Related structures

 * 1z65 Mouse Dpl residues 1-30
 * 1lg4 Human Dpl residues 24-152
 * 1i17 Mouse Dpl residues 51-157
 * 1h0l Human PrP residues 121-230, with an additional disulphide bond analogous to the homolog Doppel